Why choose between mac and cheese or meatloaf when you can have both? This Mac and Cheese Meatloaf Casserole combines the savory richness of meatloaf with the creamy decadence of mac and cheese. Layered, baked to perfection, and topped with a golden, cheesy crust, it’s the ultimate family-friendly meal that everyone will love.

Why You’ll Love This Recipe
- Two Classics, One Dish: The savory meatloaf base perfectly complements the creamy mac and cheese.
- Crowd-Pleasing: Perfect for family dinners or potlucks.
- Easy to Make: Straightforward ingredients and steps make this casserole beginner-friendly.
Ingredients
For the Meatloaf
- 1 lb ground beef
- 1/2 cup breadcrumbs
- 1/2 cup grated Parmesan cheese
- 1/4 cup milk
- 1/4 cup ketchup
- 1 large egg
- 1 tsp garlic powder
- 1 tsp onion powder
- 1 tsp salt
- 1/2 tsp black pepper
For the Mac and Cheese
- 2 cups elbow macaroni
- 2 cups shredded cheddar cheese
- 2 cups milk
- 1/4 cup unsalted butter
- 2 tbsp all-purpose flour
- 1/2 tsp mustard powder
- Salt and black pepper to taste
For the Topping
- 1/2 cup shredded cheddar cheese
- 1/4 cup breadcrumbs
Instructions
Preheat the Oven
- Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
Prepare the Meatloaf Layer
- In a large mixing bowl, combine the ground beef, breadcrumbs, Parmesan cheese, milk, ketchup, egg, garlic powder, onion powder, salt, and black pepper. Mix until fully combined.
- Press the meatloaf mixture evenly into the bottom of the prepared baking dish to create the first layer.
Cook the Macaroni
- Bring a pot of salted water to a boil and cook the elbow macaroni until al dente according to package instructions. Drain and set aside.
Make the Cheese Sauce
- In a medium saucepan over medium heat, melt the butter. Stir in the flour and cook for 1–2 minutes to form a roux.
- Gradually whisk in the milk, mustard powder, salt, and black pepper. Continue stirring frequently until the sauce thickens (about 5–7 minutes).
- Remove from heat and stir in the shredded cheddar cheese until melted and smooth.
Combine the Mac and Cheese
- Add the cooked macaroni to the cheese sauce and stir until the pasta is well coated.
Assemble the Casserole
- Spread the mac and cheese mixture evenly over the meatloaf layer in the baking dish.
- Sprinkle the additional shredded cheddar cheese and breadcrumbs over the top for a golden, crunchy crust.
Bake the Casserole
- Place the casserole in the preheated oven and bake for 25–30 minutes, or until the cheese is bubbly and the topping is golden brown.
Serve
- Let the casserole cool for a few minutes before slicing. Serve warm and enjoy this hearty, comforting dish!
Tips for Perfect Mac and Cheese Meatloaf Casserole
- Customize the Cheese: Mix in mozzarella, Monterey Jack, or gouda for a different flavor profile.
- Add Veggies: Include chopped spinach or diced bell peppers in the meatloaf layer for added nutrients.
- Use Fresh Breadcrumbs: For a crunchier topping, use homemade breadcrumbs or panko.
Why This Recipe is a Family Favorite
This Mac and Cheese Meatloaf Casserole combines the best of two comfort food classics into one dish. Its rich, savory meatloaf base and creamy, cheesy pasta topping make it the perfect dinner for any occasion. Easy to prepare and even easier to enjoy, it’s sure to become a go-to meal for busy weeknights or special gatherings.
Did you try this recipe? Share your thoughts and variations in the comments below, and follow for more family-friendly meal ideas!

Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Ingredients
- 1 lb ground beef
- 2 cups breadcrumbs
- 2 cups grated Parmesan cheese
- 4 cups milk
- 4 cups ketchup
- 1 tsp garlic powder
- 1 tsp onion powder
- 1 tsp salt
- 2 tsp black pepper
- 4 cups unsalted butter
- 2 tbsp all-purpose flour
- 2 tsp mustard powder
- 2 cups shredded cheddar cheese
- 4 cups macaroni pasta
Instructions
- Preheat the oven to 350°F (175°C).
- In a large bowl, combine the ground beef, breadcrumbs, Parmesan cheese, 1 cup of ketchup, garlic powder, onion powder, salt, and pepper. Mix until well combined.
- Press the meat mixture into the bottom of a greased casserole dish to form a base layer.
- In a saucepan, melt 4 cups of butter over medium heat. Stir in the flour and cook for 1 minute.
- Slowly whisk in the milk and continue to stir until the mixture thickens.
- Add the mustard powder and shredded cheddar cheese to the sauce, stirring until the cheese is melted and creamy.
- Cook the macaroni according to package instructions, then drain and fold it into the cheese sauce.
- Pour the mac and cheese mixture over the meatloaf base in the casserole dish.
- Spread the remaining ketchup on top of the mac and cheese layer.
- Top with additional breadcrumbs if desired.
- Bake in the preheated oven for 30 minutes or until the top is golden and bubbly.
- Let cool for a few minutes before serving.
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